Formulation and evaluation of transdermal patches for the treatment of arthritis

Abstract

The most common side effects of Leflunomide are such as dyspepsia, nausea, abdominal pain, and oral ulceration. The benefits of transdermal patches include increased permeability of drug good skin penetration, avoidance of first pass metabolism. Increase drug delivery of leflunomide which result in increased concentration of drug at the site of action. The objective of making is formulation is to ensure that the drug remains on the inflamed tissue for a long time so that the drug can have better action